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Publié le 24/06/2007 à 19:26
Par lovastatin
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The age at which lipid-lowering drug therapy should be started in patients with familial hypercholesterolemia and premature coronary disease is not well defined, although there is agreement that drug therapy should be started in such patients if a low-fat diet fails to reduce the low-density lipoprotein (LDL) cholesterol level to below 160 mg per dL (4.2 mmol per L). Pharmacologic intervention is also generally advocated in patients without a family history of premature coronary disease if the LDL level remains above 190 mg per dL (4.9 mmol per L). Bile-acid sequestrants, which have a relatively long history of use in children with familial hypercholesterolemia, are generally the drugs of choice, but these agents do not have a major effect on LDL levels. Stein and colleagues conducted a study to determine if a statin (specifically, lovastatin) is safe and effective in the treatment of adolescent males with heterozygous familial hypercholesterolemia.
A total of 132 boys 10 to 17 years of age were enrolled in the double- blind, placebo-controlled study; 110 completed the 48-week study. In all of the boys, LDL levels (despite dietary measures) had measured at least 189 mg per dL (4.9 mmol per L). All of the subjects had a family history of one parent with similarly elevated LDL levels or of a parent who died as a result of coronary artery disease. Tanner stage was assessed at recruitment and at 24 and 48 weeks after study entry. Height, weight, lipid profile, liver function and diet were monitored periodically throughout the study. Dietary instruction was provided.
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Publié le 24/06/2007 à 19:18
Par lovastatin
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GENERIC NAME: lovastatin
BRAND NAME: Mevacor, Altocor
DRUG CLASS AND MECHANISM: Lovastatin is a cholesterol- lowering medicine. It inhibits the production of cholesterol by the liver. It lowers overall blood cholesterol as well as blood LDL cholesterol levels. LDL cholesterol is believed to be the "bad" cholesterol that is primarily responsible for the development of coronary artery disease. Lowering LDL cholesterol levels retards progression and may even reverse coronary artery disease. PRESCRIPTION: Yes GENERIC AVAILABLE: Yes PREPARATIONS: Tablets: 10, 20, and 40 mg. Extended release tablets: 10, 20, 40, and 60 mg. STORAGE: Tablets should be stored at room temperature in a tightly closed container. PRESCRIBED FOR: High LDL cholesterol is usually first treated with exercise, weight loss in obese individuals, and a diet low in cholesterol and saturated fats. When these measures fail, cholesterol-lowering medications such as lovastatin can be added. The National Cholesterol Education Program (NCEP) has published treatment guidelines for use of these medications. These treatment guidelines take into account the level of LDL cholesterol as well as the presence of other risk factors such as diabetes, hypertension, cigarette smoking, low HDL cholesterol level, and family history of early coronary heart disease. The effectiveness of the medication in lowering cholesterol is dose- related. Blood cholesterol determinations are performed in regular intervals during treatment so that dosage adjustments can be made. A reduction in LDL cholesterol level can be seen two weeks after starting therapy. DOSING: May be taken on an empty or full stomach. The medication seems to be most effective when given with the evening meal. DRUG INTERACTIONS: Lovastatin is generally well- tolerated by most patients. The medication should be used with caution in patients with alcohol or other liver diseases. Persistent abnormal liver tests during treatment are rare, but may lead to the discontinuation of the medication. Rare cases of muscle inflammation (myositis) and breakdown have been reported with lovastatin. Muscle breakdown causes release of muscle protein (myoglobin) into the blood and kidney tubules, resulting in kidney failure. Severe muscle breakdown and kidney failure have been reported when lovastatin is used together with gemfibrozil (Lopid). Therefore their concomitant use is discouraged. The risk of muscle breakdown is also increased when lovastatin is given together with other medications, such as cyclosporine (Sandimmune), erythromycin and nicotinic acid. Therefore, lovastatin should be used with caution and in lower doses when medications, such as cyclosporine are also needed. Lovastatin should not be used by children. It is not habit forming. PREGNANCY: Lovastatin may cause fetal harm, and should not be given to pregnant women. NURSING MOTHERS: Lovastatin should not be used by nursing mothers because of potential adverse side effects to the nursing infant. SIDE EFFECTS: Side effects are rare. Minor side effects include constipation, diarrhea, gas, heartburn, headache, insomnia. Major side effects include abdominal pain or cramps, blurred vision, dizziness, itching, muscle pain or cramps, rash, yellowing of the skin or eyes.
Publié le 24/06/2007 à 19:02
Par lovastatin
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Lovastatin Side Effects: An Introduction
As with any medicine, there are possible side effects with Lovastatin tablets ("lovastatin"). However, not everyone who takes lovastatin will develop problems. In fact, most people tolerate lovastatin well. When side effects do occur, they are usually minor and either require no treatment or can easily be treated by you or a healthcare professional. In previous research studies, up to 4.6 percent of people taking lovastatin stopped their medicine because of side effects.
If you develop unexplained muscle pain, tenderness, or weakness while taking lovastatin, especially if the symptoms are with a fever or you feel ill, it is important to contact your healthcare provider immediately.
(The side effects discussed below are not a complete list of side effects reported with lovastatin. Your healthcare provider can discuss a more complete list of lovastatin side effects with you.)
Common Lovastatin Side Effects
Lovastatin has been studied extensively in clinical trials, with thousands of people having been evaluated. In these studies, side effects are always documented and compared to side effects that occur in a similar group of people not taking the medicine. Based on these studies, the most common lovastatin side effects include:
* Gas -- up to 4.5 percent of people
* Constipation -- up to 3.5 percent of people
* Headache -- up to 3.2 percent of people
* Muscle pain, known medically as myalgia -- up to 3 percent of people (see Mevacor and Muscle Pain)
* Diarrhea -- up to 2.6 percent of people
* Abdominal pain -- up to 2.5 percent of people.
The lovastatin side effects mentioned below also occurred in more than one percent of people, and more often in the group taking lovastatin. These common side effects of lovastatin included, but were not limited to:
* General feeling of weakness, known medically as asthenia
* Indigestion, known medically as dyspepsia
* Nausea
* Muscle cramps
* Dizziness
* Unexplained rash
* Blurred vision.
Publié le 24/06/2007 à 18:54
Par lovastatin
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Lovastatin As this eMedTV article explains, lovastatin is a prescription drug that is licensed for treating conditions such as high cholesterol and triglycerides. This page offers an in-depth look at lovastatin and its uses, dosing, and possible side effects.
What Is Lovastatin Used For?
What is lovastatin used for? As this eMedTV article explains, lovastatin is a drug that is used for the treatment of high cholesterol and triglycerides, as well as the prevention of heart disease. This page also discusses lovastatin use in children.
Lovastatin Side Effects
Lovastatin side effects may include gas, nausea, and headache. This part of the eMedTV library offers a more complete list of common and rare lovastatin side effects, including information on symptoms you should report to your doctor immediately.
Dosing With Lovastatin
Dosing with lovastatin generally starts at 20 mg for adults and 10 mg to 20 mg for children. As this eMedTV page explains, depending on whether cholesterol goals are reached or if side effects occur, dosages can be adjusted accordingly. Drug Interactions With Lovastatin Some of the drugs that can interact with lovastatin include digoxin, niacin, and fibrates. As this eMedTV page explains, some of the drug interactions with lovastatin can cause severe side effects and complications, including serious muscle problems.
Precautions and Warnings of Lovastatin
If you have kidney damage and are taking lovastatin, you are at risk of developing serious muscle problems. This eMedTV page lists other precautions and warnings of lovastatin, including information on who shouldn't take the drug.
Lovastatin Extended-Release
This page on the eMedTV Web site discusses the prescription medication lovastatin extended-release, which is used to treat high cholesterol and high triglycerides. This article outlines uses, dosing, and alternatives for this medication.
Publié le 24/06/2007 à 18:47
Par lovastatin
Lovastatin extended-release helps lower cholesterol and triglycerides by blocking the enzyme HMG-CoA reductase, which controls the body's rate of cholesterol production. In previous research studies, people taking lovastatin extended-release 20 mg once a day were able to lower their LDL cholesterol ("bad cholesterol") by 30 percent and their total cholesterol by 21 percent -- and increase their HDL cholesterol ("good cholesterol") by 12 percent. Larger doses had an even greater effect on cholesterol and triglyceride levels. Common side effects include muscle pain, joint pain, and inflammation of the sinuses (sinusitis).
An Overview of Lovastatin Extended-ReleaseLovastatin extended-release (Altoprev®) is a prescription medication used for treating a number of conditions related to heart disease, including high cholesterol and high triglycerides. It is part of a class of drugs called HMG-CoA reductase inhibitors, which are more popularly known as statins.
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Lovastatin extended-release has been licensed for several uses including:
* Treatment of high cholesterol (hypercholesterolemia)
* Treatment of high triglycerides
* Prevention of heart disease.
Lovastatin extended-release is part of a class of drugs called statins. It works by blocking a particular enzyme, HMG-CoA reductase, that controls the rate of cholesterol production in the body. This causes the liver to make less cholesterol. Lovastatin extended-release also:
* Increases the liver's ability to collect and get rid of LDL cholesterol ("bad cholesterol")
* Increases HDL cholesterol ("good cholesterol")
* Decreases triglycerides.
 
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